解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::During chronic inflammation, interleukin (IL)-22 expression is up-regulated in both CD4 and CD8 T cells, exerting a protective role in infections. However, in autoimmunity, IL-22 appears to have either a protective or a pathogenic role in a variety of murine models of autoimmunity and, by extrapolation, in humans. It ...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12806
更新日期:2016-08-01 00:00:00
abstract::The aim of this study was to provide proof-of-concept for quantitative and qualitative label-free detection of immune complexes through myeloid cells with imaging surface plasmon resonance. Surface plasmon resonance imaging was first applied to monitor the binding of human sera from healthy and rheumatoid arthritis (R...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12788
更新日期:2016-07-01 00:00:00
abstract::Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12789
更新日期:2016-07-01 00:00:00
abstract::Post-kala-azar dermal leishmaniasis (PKDL) is a chronic dermal complication that occurs usually after recovery from visceral leishmaniasis (VL). The disease manifests into macular, papular and/or nodular clinical types with mono- or polymorphic presentations. Here, we investigated differences in immunological response...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12787
更新日期:2016-07-01 00:00:00
abstract::The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12782
更新日期:2016-06-01 00:00:00
abstract::The systemic inflammatory response is a challenge in the management of paediatric patients undergoing cardiac surgery. Although multi-factorial, a contribution by the lectin pathway of complement activation has been postulated. We therefore investigated the changes in serum levels of mannose binding lectin (MBL) and a...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12763
更新日期:2016-05-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast-like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and certain proinflammatory cytokines may affect synoviocyte invasio...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12751
更新日期:2016-05-01 00:00:00
abstract::Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of ce...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12723
更新日期:2016-03-01 00:00:00
abstract::Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is characterized by the deposition of subepithelial immune deposits that consist mainly of immunoglobulin (Ig)G and complement. Most of the cases are primary or idiopathic (iMN), while only approximately 25% of the cases are secondary to s...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章,评审
doi:10.1111/cei.12729
更新日期:2016-02-01 00:00:00
abstract::Reliable risk assessment for biotherapeutics requires accurate evaluation of risk factors associated with immunogenicity. Immunogenicity risk assessment tools were developed and applied to investigate the immunogenicity of a fully human therapeutic monoclonal antibody, ATR-107 [anti-interleukin (IL)-21 receptor] that ...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12711
更新日期:2016-01-01 00:00:00
abstract::Immunoglobulin variable region heavy chain (IgVH ) somatic gene diversification is instrumental in the transformation process that characterizes hepatitis C virus (HCV)-related B cell lymphoproliferative disorders. However, the extent to which activation-induced cytidine deaminase (AID), an enzyme essential for IgV ge...
journal_title:Clinical and experimental immunology
pub_type: 临床试验,杂志文章
doi:10.1111/cei.12690
更新日期:2015-12-01 00:00:00
abstract::The efficacy of steroids and immunosuppressive treatments in idiopathic nephrotic syndrome (INS) hints at the implication of immune cells in the pathophysiology of the disease. Toll-like receptor (TLR) dysfunctions are involved in many kidney diseases of immune origin, but remain little described in INS. We investigat...
journal_title:Clinical and experimental immunology
pub_type: 临床试验,杂志文章
doi:10.1111/cei.12659
更新日期:2015-12-01 00:00:00
abstract::Leishmania parasites are the causative agents of leishmaniasis, a neglected tropical disease that causes substantial morbidity and considerable mortality in many developing areas of the world. Recent estimates suggest that roughly 10 million people suffer from cutaneous leishmaniasis (CL), and approximately 76,000 are...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章,评审
doi:10.1111/cei.12674
更新日期:2015-11-01 00:00:00
abstract::The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sjögren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12683
更新日期:2015-11-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a persistent virus with oncogenic capacity that has been implicated in the development of aggressive B cell lymphomas, primarily in immunosuppressed individuals, although it can be present in immunocompetent individuals. Changes in the function and clonal diversity of T lymphocytes might be...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12682
更新日期:2015-11-01 00:00:00
abstract::A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monoc...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12667
更新日期:2015-10-01 00:00:00
abstract::The aim of this study was to investigate the diagnostic value of using the copy number of propionibacterial rRNA as a biomarker for sarcoidosis. Ribosomal RNA of Propionibacterium acnes and P. granulosum was measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) using formalin-fixe...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12650
更新日期:2015-09-01 00:00:00
abstract::We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline...
journal_title:Clinical and experimental immunology
pub_type: 临床试验,杂志文章
doi:10.1111/cei.12626
更新日期:2015-09-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) remains the only available and most widely administered vaccine against Mycobacterium tuberculosis (Mtb), yet it fails to protect vaccinated individuals either from primary infection or reactivation of latent tuberculosis (TB). Despite BCG's variable efficacy against TB, the fact remains...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12634
更新日期:2015-08-01 00:00:00
abstract::Amyloid A (AA) amyloidosis is characterized by extracellular pathogenic deposition of insoluble fibril protein in various body organs. Deposited amyloid generally remains in a variety of organs for long periods, but its disappearance has been reported after the precursor protein is diminished. The kinetics of AA depos...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12615
更新日期:2015-07-01 00:00:00
abstract::Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are often characterized by a failure of self-tolerance and result in an uncontrolled activation of B cells and effector T cells. Interleukin (IL)-2 critically maintains homeostasis of regulatory T cells (T(reg)) and effector T cells in the perip...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12629
更新日期:2015-07-01 00:00:00
abstract::Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12624
更新日期:2015-07-01 00:00:00
abstract::In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12621
更新日期:2015-07-01 00:00:00
abstract::We analysed the proportions of different microparticles (MPs) in plasma from patients with rheumatoid arthritis (RA), and assessed their relationship with disease activity/therapy and their in-vitro effect on proinflammatory cytokine release. Blood and urine samples were obtained from 55 patients with RA (24 untreated...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12598
更新日期:2015-06-01 00:00:00
abstract::The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play an important pathogenic role in murine arthritis. To clarify their pathophysiological roles in patients with rheumatoid arthritis (RA), we examined their expression and localization in peripheral blood mononuclear cells (PBMC). TNFAIP9 and ...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12606
更新日期:2015-06-01 00:00:00
abstract::Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid 180. This study was performed to characterize and map the fine specificity of T cell responses to NC16a. Peripheral blood mononuclear cells (PBMC) from a total of 28 bullous pemphigoid patient...
journal_title:Clinical and experimental immunology
pub_type: 临床试验,杂志文章
doi:10.1111/cei.12566
更新日期:2015-05-01 00:00:00
abstract::Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous studies have concentrated on circulating autoantibodies, but lung-associa...
journal_title:Clinical and experimental immunology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/cei.12565
更新日期:2015-04-01 00:00:00
abstract::T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relative expression of intact forkhead box protein 3 (FoxP3) compared to FoxP3Δ2, ...
journal_title:Clinical and experimental immunology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/cei.12557
更新日期:2015-04-01 00:00:00
abstract::Autoantibodies inhibiting the activity of the metalloproteinase, ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), underlie the pathogenesis of thrombotic thrombocytopenic purpura (TTP). Rituximab (RTX) combined with plasma-exchange (PEX) is an effective treatment in TTP. Pa...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12472
更新日期:2015-03-01 00:00:00
abstract::Expression of the adhesion molecule, CD146/MCAM/MelCAM, on T cells has been associated with recent activation, memory subsets and T helper type 17 (Th17) effector function, and is elevated in inflammatory arthritis. Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA) and spondyloarthritide...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12434
更新日期:2015-03-01 00:00:00
abstract::Cell death and the release of chromatin have been demonstrated to activate the immune system producing autoantibodies against nuclear antigens in patients with systemic lupus erythematosus (SLE). Apoptosis, necrosis, necroptosis, secondary necrosis, autophagy and the clearance of dying cells by phagocytosis are proces...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章,评审
doi:10.1111/cei.12417
更新日期:2015-01-01 00:00:00
abstract::Recently we reported the first known incidence of antibodies possessing catalytic sialidase activity (sialidase abzymes) in the serum of patients with multiple myeloma and systemic lupus erythematosus (SLE). These antibodies desialylate biomolecules, such as glycoproteins, gangliosides and red blood cells. Desialylati...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12312
更新日期:2015-01-01 00:00:00
abstract::We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement o...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12416
更新日期:2014-11-01 00:00:00
abstract::Functional analysis of single Toll-like receptors (TLRs) in vivo is necessary to understand how they shape the ocular inflammation involved in uveitis. In this study we explored the role and mechanisms of TLR-2 agonists on the autoreactive T helper type 17 (Th17) response in experimental autoimmune uveitis (EAU). Trea...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12405
更新日期:2014-11-01 00:00:00
abstract::Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate, kidney diseases, autoimmune- or neurodegenerative diseases and i...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12388
更新日期:2014-10-01 00:00:00
abstract::Calculated globulin (total protein - albumin) is usually tested as part of a liver function test profile in both primary and secondary care and determines the serum globulin concentration, of which immunoglobulins are a major component. The main use hitherto of calculated globulin is to detect paraproteins when the le...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12369
更新日期:2014-09-01 00:00:00
abstract::Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12370
更新日期:2014-09-01 00:00:00
abstract::Sarcoidosis is a systemic, inflammatory disorder, which in a proportion of patients runs a chronic progressive course despite immunosuppressive treatment. Therapeutic granulocyte and monocyte apheresis (GMA) has been shown to be an effective treatment option for other systemic inflammatory disorders, but has not yet b...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12360
更新日期:2014-09-01 00:00:00
abstract::It has always been known that anti-tissue transglutaminase 2 (anti-TG2) antibodies are produced in the small intestine. Their serum titres correlate with mucosal damage degree and decrease on a gluten-free diet (GFD). We aimed to correlate intestinal anti-TG2 antibodies levels with degree of mucosal damage and GFD dur...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12366
更新日期:2014-09-01 00:00:00
abstract::Human cartilage gp-39 (HC gp-39) is a well-known autoantigen in rheumatoid arthritis (RA). However, the exact localization, fluctuation and function of HC gp-39 in RA are unknown. Therefore, using a glucose-6-phosphate isomerase (GPI)-induced model of arthritis, we investigated these aspects of HC gp-39 in arthritis. ...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/cei.12349
更新日期:2014-08-01 00:00:00